Computational Biology

Our goal is an improved understanding of the genetic basis of gene regulation and its implication in diseases. To this end, we employ statistical modeling of 'omic data and work in close collaboration with experimentalists.



On top of our main affiliation at the School of Computation, Information and Technology, we are proud members of the School of Medicine,  the Munich Data Science Institute, and the Computational Health Center of Helmholtz Munich.

Moreover, our lab is part of the graduate schools Munich School for Data Science  and Quantitative Bioscience Munich.

Selected Publications

Avsec et al. The Kipoi repository accelerates community exchange and reuse of predictive models for genomics, Nature biotechnology (2019)

Kremer et al. Genetic diagnosis of Mendelian disorders via RNA sequencing. Nature Communications (2017)

Schwalb et al. TT-seq maps the human transient transcriptome. Science (2016)

Eser et al. Determinants of RNA metabolism in the S. pombe genome. Mol Syst Biol (2016)

Bader et al. Negative feedback buffers effects of regulatory variants. Mol Syst Biol (2015)

Gagneur et al. Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. PLoS Genet (2013)

Xu et al. Antisense expression increases gene expression variability and locus interdependency. Mol Syst Biol (2011)

Bauer et al. GOing Bayesian: model-based gene set analysis of genome-scale data. Nucleic Acids Res (2010)

Zinzen et al. Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature (2009)

Xu et al. Bidirectional promoters generate pervasive transcription in yeast. Nature (2009)