Dr. Matthias Keicher

Research Interests

• Calibrated uncertainty in clinical language models: training models to express what they do not know, so a system can defer instead of answering confidently and wrongly (Rewarding Doubt, ICLR 2026; ConRad, MICCAI 2026)
• Clinical reasoning agents that choose what to examine next: diagnosis as a sequential decision process in which the model requests the next informative examination before committing, trained with reinforcement learning (LA-CDM, ICLR 2026)
• Structured, verifiable radiology reporting: generating and evaluating findings against a clinically grounded schema rather than a text-similarity score, so errors are measured where they matter clinically (RaDialog, Rad-ReStruct, FlexR)
• Interpretable diagnosis from medical images: concept-level explanations a radiologist can check, and counterfactuals that show what would have changed the prediction (Xplainer, DIVA, diffusion autoencoders)
• Longitudinal patient modelling and clinical world models: integrating prior imaging, earlier reports and clinical context across a disease course, and simulating how that course responds to treatment, so therapy decisions can be optimised over the whole trajectory (EHR2Path, TMLR 2026)

Curriculum vitae

Matthias Keicher leads the Vision-Language Group at the Chair for Computer Aided Medical Procedures and manages the Interdisciplinary Research Lab (IFL) at Klinikum rechts der Isar in Munich since 2023. His group builds clinical decision support that reasons over imaging, prior reports and patient context. Current work spans structured radiology reporting, calibrated uncertainty in clinical language models, and longitudinal modelling of disease courses, in close collaboration with the Departments of Radiology and Neuroradiology at Klinikum rechts der Isar.

• 12/2024 - current: Postdoc and Group Leader at the Chair for Computer Aided Medical Procedures
• 01/2025 - 03/2025: Visiting Researcher, Stanford University, School of Medicine; Multimodal foundation models for radiology with Akshay Chaudhari
• 09/2019 - 12/2024: PhD student at the Chair for Computer Aided Medical Procedures
• 02/2019 - 12/2024: Research Manager at the Chair for Computer Aided Medical Procedures
• 08/2016 - 12/2018: CTO and Managing Director of SurgicEye GmbH
  • Dosimetry, interventional radiology and radio-embolisation
• 05/2015 - 07/2016: Director of Business Development, SurgicEye GmbH
  • Minimally-invasive breast cancer staging
• 09/2013 - 04/2015: Product Manager, SurgicEye GmbH
  • Intraoperative SPECT imaging and Ultrasound fusion
• 10/2006 - 06/2013: Mechanical Engineering and Management at TUM (Dipl.-Ing.)
  • Focus on biomedical engineering and medical devices

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